Ritter-type amination of C(sp³)-H bonds enabled by electrochemistry with SO₄².

ABSTRACT: By merging electricity with sulfate, the Ritter-type amination of C(sp³)-H bonds is developed in an undivided cell under room temperature. This method features broad substrate generality (71 examples, up to 93% yields), high functional-group compatibility, facile scalability, excellent site-selectivity and mild conditions. Common alkanes and electron-deficient alkylbenzenes are viable substrates. It also provides a straightforward protocol for incorporating C-deuterated acetylamino group into C(sp³)-H sites. Application in the synthesis or modification of pharmaceuticals or their derivatives and gram-scale synthesis demonstrate the practicability of this method. Mechanistic experiments show that sulfate radical anion, formed by electrolysis of sulfate, served as hydro

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9288499 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature