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C-H Amination via Electrophotocatalytic Ritter-type Reaction.

ABSTRACT: A method for C-H bond amination via an electrophotocatalytic Ritter-type reaction is described. The reaction is catalyzed by a trisaminocyclopropenium (TAC) ion in an electrochemical cell under irradiation. These conditions convert benzylic C-H bonds to acetamides without the use of a stoichiometric chemical oxidant. A range of functionality is shown to be compatible with this transformation, and several complex substrates are demonstrated.

SUBMITTER: Shen T

PROVIDER: S-EPMC8935655 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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C-H Amination via Electrophotocatalytic Ritter-type Reaction.

Shen Tao T Lambert Tristan H TH

Journal of the American Chemical Society 20210602 23

A method for C-H bond amination via an electrophotocatalytic Ritter-type reaction is described. The reaction is catalyzed by a trisaminocyclopropenium (TAC) ion in an electrochemical cell under irradiation. These conditions convert benzylic C-H bonds to acetamides without the use of a stoichiometric chemical oxidant. A range of functionality is shown to be compatible with this transformation, and several complex substrates are demonstrated. ...[more]

PMID: 34076424

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