Ontology highlight
ABSTRACT:
SUBMITTER: Monasterolo C
PROVIDER: S-EPMC9274776 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Organic letters 20220628 26
The first example of an aromatic haloform reaction is reported, defining a conceptually new haloform-type approach to the metal-free functionalization of arenes. We demonstrated that heteroarenes bearing a vinylogous nitromethane system, via the stage of a trichloromethane derivative, could undergo aromatic amination to produce N-functionalized arenes in quantitative yields and without the need for transition-metal catalysis. The haloform-type amination was implemented in the development of effe ...[more]