Dataset Information

The Landscape of Immune Microenvironments in Racially Diverse Breast Cancer Patients.

ABSTRACT:

Background

Immunotherapy is a rapidly evolving treatment option in breast cancer; However, the breast cancer immune microenvironment is understudied in Black and younger (<50 years) patients.

Methods

We used histologic and RNA-based immunoprofiling methods to characterize the breast cancer immune landscape in 1,952 tumors from the Carolina Breast Cancer Study (CBCS), a population-based study that oversampled Black (n = 1,030) and young women (n = 1,039). We evaluated immune response leveraging markers for 10 immune cell populations, compared profiles to those in The Cancer Genome Atlas (TCGA) Project [n = 1,095 tumors, Black (n = 183), and young women (n = 295)], and evaluated in association with clinical and demographic variables, including recurrence.

Results

Consensus clustering identified three immune clusters in CBCS (adaptive-enriched, innate-enriched, or immune-quiet) that varied in frequency by race, age, tumor grade and subtype; however, only two clusters were identified in TCGA, which were predominantly comprised of adaptive-enriched and innate-enriched tumors. In CBCS, the strongest adaptive immune response was observed for basal-like, HER2-positive (HER2+), triple-negative breast cancer (TNBC), and high-grade tumors. Younger patients had higher proportions of adaptive-enriched tumors, particularly among estrogen receptor (ER)-negative (ER-) cases. Black patients had higher frequencies of both adaptive-enriched and innate-enriched tumors. Immune clusters were associated with recurrence among ER- tumors, with adaptive-enriched showing the best and innate-enriched showing the poorest 5-year recurrence-free survival.

Conclusions

These data suggest that immune microenvironments are intricately related to race, age, tumor subtype, and grade.

Impact

Given higher mortality among Black and young women, more defined immune classification using cell-type-specific panels could help explain higher recurrence and ultimately lead to targetable interventions.

SUBMITTER: Hamilton AM

PROVIDER: S-EPMC9292136 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Publications

The Landscape of Immune Microenvironments in Racially Diverse Breast Cancer Patients.

Hamilton Alina M AM Hurson Amber N AN Olsson Linnea T LT Walens Andrea A Nsonwu-Farley Joseph J Kirk Erin L EL Abdou Yara Y Downs-Canner Stephanie M SM Serody Jonathan S JS Perou Charles M CM Calhoun Benjamin C BC Troester Melissa A MA Hoadley Katherine A KA

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20220701 7

<h4>Background</h4>Immunotherapy is a rapidly evolving treatment option in breast cancer; However, the breast cancer immune microenvironment is understudied in Black and younger (<50 years) patients.<h4>Methods</h4>We used histologic and RNA-based immunoprofiling methods to characterize the breast cancer immune landscape in 1,952 tumors from the Carolina Breast Cancer Study (CBCS), a population-based study that oversampled Black (n = 1,030) and young women (n = 1,039). We evaluated immune respon ...[more]

PMID: 35437570

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Dataset Information

The Landscape of Immune Microenvironments in Racially Diverse Breast Cancer Patients.

Background

Methods

Results

Conclusions

Impact

Publications

The Landscape of Immune Microenvironments in Racially Diverse Breast Cancer Patients.

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