The Landscape of Immune Microenvironments in Racially Diverse Breast Cancer Patients.

ABSTRACT:

Background

Immunotherapy is a rapidly evolving treatment option in breast cancer; However, the breast cancer immune microenvironment is understudied in Black and younger (<50 years) patients.

Methods

We used histologic and RNA-based immunoprofiling methods to characterize the breast cancer immune landscape in 1,952 tumors from the Carolina Breast Cancer Study (CBCS), a population-based study that oversampled Black (n = 1,030) and young women (n = 1,039). We evaluated immune response leveraging markers for 10 immune cell populations, compared profiles to those in The Cancer Genome Atlas (TCGA) Project [n = 1,095 tumors, Black (n = 183), and young women (n = 295)], and evaluated in association with clinical and demographic variables, including recurrence.

Results

Consen

SUBMITTER: Hamilton AM 

PROVIDER: S-EPMC9292136 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature