Blimp-1 is a prognostic indicator for progression of cervical intraepithelial neoplasia grade 2.

ABSTRACT:

Background

Progression of cervical intraepithelial neoplasia (CIN) to higher grade disease is associated with persistent human papillomavirus (HPV) infection and an absence of immune-mediated regression. However, the immune microenvironment that distinguishes progression from persistent or regressing lesions has not been well defined.

Methods

A total of 69 patients under the age of 25 with high-risk HPV-positive cytology and biopsy-confirmed p16-positive CIN2 were included in the study. Biopsies were stained using 20 antibodies to a range of immune markers. Based on a 2-year follow-up, samples were analysed in "progressor" (CIN3 +) or "persister/regressor" (CIN1, 2 or normal) groups.

Results

Progression was most strongly associated with Blimp-1 positive cell staining

SUBMITTER: Saito M 

PROVIDER: S-EPMC9294030 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature