The Role of PPAR-gamma C161T Polymorphism in Colorectal Cancer Susceptibility.

ABSTRACT:

Background/aim

This study aimed to determine the role of the peroxisome proliferator-activated receptor-gamma (PPARg) C161T genotype and allele frequencies in predisposition to colorectal cancer (CRC).

Patients and methods

PPARg C161T (His447His; rs3856806) gene polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism analysis in patients with CRC (n=101) and controls (n=238).

Results

The T161 allele (CT+TT genotypes) of PPARg C161T polymorphism was associated with CRC development (p<0.001; OR=3.239, 95%CI=1.997-5.252). Subgroup analysis showed that the T161 allele was associated with a 3.056-fold increased risk for colon cancer (CC) (p<0.001; 95%CI=1.709-5.464) and 3.529-fold increased risk for rectal cancer (RC) (p<0.001; 9

SUBMITTER: Kurnaz-Gomleksiz O 

PROVIDER: S-EPMC9301400 | biostudies-literature | 2022 Jul-Aug

REPOSITORIES: biostudies-literature