Association of leptin receptor gene Gln223Arg polymorphism with susceptibility to colorectal cancer.

ABSTRACT:

Aim

Leptin is a 16 kDa polypeptide hormone which secreted by adipose tissue and has an important role in energy balance, insulin pathway and inflammation, because of that it may play an important role in colorectal cancer (CRC). Leptin exerts its effect through the leptin receptor (LEPR) a member of the class I cytokine receptor family.

Background

We have investigated whether glutamine to arginine substitution (Gln223Arg) in exon 6 of the leptin receptor gene, has implications for susceptibility to CRC.

Patients and methods

Polymerase chain reaction (PCR) and restriction enzyme digestion (RFLP) was performed to evaluate the association between the Gln223Arg polymorphism of the LEPR and CRC risk in a case-control study in 346 subjects involving 173 cases with CRC and 1

SUBMITTER: Karimi K 

PROVIDER: S-EPMC4017430 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature