History of proliferative glomerulonephritis predicts end stage kidney disease in pure membranous lupus nephritis.

ABSTRACT:

Objectives

Pure membranous (class V) LN is considered a less aggressive phenotype, but tissue fibrosis and chronic kidney disease may still develop. This study aimed to elucidate the prognostic value of a history of class switch in pure membranous LN.

Methods

We included LN patients with at least two clinically indicated kidney biopsies. New onset of end stage kidney disease (ESKD) was defined as estimated glomerular filtration rate <15 ml/min/1.73 m2, initiation of dialysis or kidney transplantation.

Results

Among 220 patients (542 biopsies), 199 (90%) were female, and 118 (54%) were African American, 59 (27%) Caucasian, with median age of 28 years at the first kidney biopsy. Patients with pure class V in a first biopsy converted to proliferative LN in 41% of cases.

SUBMITTER: Fava A 

PROVIDER: S-EPMC9308381 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature