Type I conventional dendritic cells relate to disease severity in virus-induced asthma exacerbations.

ABSTRACT:

Rationale

Rhinoviruses are the major precipitant of asthma exacerbations and individuals with asthma experience more severe/prolonged rhinovirus infections. Concurrent viral infection and allergen exposure synergistically increase exacerbation risk. Although dendritic cells orchestrate immune responses to both virus and allergen, little is known about their role in viral asthma exacerbations.

Objectives

To characterize dendritic cell populations present in the lower airways, and to assess whether their numbers are altered in asthma compared to healthy subjects prior to infection and during rhinovirus-16 infection.

Methods

Moderately-severe atopic asthmatic patients and healthy controls were experimentally infected with rhinovirus-16. Bronchoalveolar lavage was collect

SUBMITTER: Cameron A 

PROVIDER: S-EPMC9310571 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature