Association between Temporal Glycemic Change and Risk of Pancreatic Cancer in Men: A Prospective Cohort Study.

ABSTRACT: Hyperglycemia has been reported to increase the risk of pancreatic cancer (PC), while the association between glycemic change and PC risk has rarely been explored. Using data from a prospective cohort study conducted in China since 2006, 138,870 males with available fasting blood glucose (FBG) levels, including 106,632 males with at least two FBG measurements, were analyzed. The associations between FBG (level, change, and stability) and PC incidence were evaluated using Cox proportional hazard regression and restricted cubic splines. Baseline (p = 0.109) and recent (p = 0.070) FBG levels and incident PC were not significantly associated. U-shaped associations were observed between the annual FBG change and PC risk. Compared with stable FBG, participants with annual FBG chang

SUBMITTER: Cai J 

PROVIDER: S-EPMC9323305 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature