Estimating baseline kidney function in hospitalized adults with acute kidney injury.

ABSTRACT:

Aim

Baseline serum creatinine values are required to diagnose acute kidney injury but are often unavailable. We evaluated four conventional equations to estimate creatinine. We then developed and validated a new equation corrected by age and gender.

Methods

We retrospectively examined adults who, at first hospital admission, had available baseline creatinine data and developed acute kidney injury ≥24 h after admission. We split the study population: 50% (derivation) to develop a new linear equation and 50% (validation) to compare against conventional equations for bias, precision, and accuracy. We stratified analyses by age and gender.

Results

We studied 3139 hospitalized adults (58% male, median age 71). Conventional equations performed poorly in bias and accuracy in

SUBMITTER: Larsen T 

PROVIDER: S-EPMC9325517 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature