On the Versatility of Nanozeolite Linde Type L for Biomedical Applications: Zirconium-89 Radiolabeling and In Vivo Positron Emission Tomography Study.

ABSTRACT: Porous materials, such as zeolites, have great potential for biomedical applications, thanks to their ability to accommodate positively charged metal-ions and their facile surface functionalization. Although the latter aspect is important to endow the nanoparticles with chemical/colloidal stability and desired biological properties, the possibility for simple ion-exchange enables easy switching between imaging modalities and/or combination with therapy, depending on the envisioned application. In this study, the nanozeolite Linde type L (LTL) with already confirmed magnetic resonance imaging properties, generated by the paramagnetic gadolinium (Gd^III) in the inner cavities, was successfully radiolabeled with a positron emission tomography (PET)-tracer zirconium-89 (⁸⁹

SUBMITTER: Lacerda S 

PROVIDER: S-EPMC9335405 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature