PO2RDF: representation of real-world data for precision oncology using resource description framework.

ABSTRACT:

Background

Next-generation sequencing provides comprehensive information about individuals' genetic makeup and is commonplace in precision oncology practice. Due to the heterogeneity of individual patient's disease conditions and treatment journeys, not all targeted therapies were initiated despite actionable mutations. To better understand and support the clinical decision-making process in precision oncology, there is a need to examine real-world associations between patients' genetic information and treatment choices.

Methods

To fill the gap of insufficient use of real-world data (RWD) in electronic health records (EHRs), we generated a single Resource Description Framework (RDF) resource, called PO2RDF (precision oncology to RDF), by integrating information regarding gen

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9338627 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature