Proteome and phosphoproteome signatures of recurrence for HPV⁺ head and neck squamous cell carcinoma.

ABSTRACT:

Background

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and the human papillomavirus (HPV⁺)-driven subtype is the fastest rising cancer in North America. Although most cases of HPV⁺ HNSCC respond favorably to the treatment via surgery followed by radiochemotherapy, up to 20% recur with a poor prognosis. The molecular and cellular mechanisms of recurrence are not fully understood.

Methods

To gain insights into the mechanisms of recurrence and to inform patient stratification and personalized treatment, we compared the proteome and phosphoproteome of recurrent and non-recurrent tumors by quantitative mass spectrometry.

Results

We observe significant differences between the recurrent and non-recurrent tumor

SUBMITTER: Kaneko T 

PROVIDER: S-EPMC9338924 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature