B vitamin intakes modify the association between particulate air pollutants and incidence of all-cause dementia: Findings from the Women's Health Initiative Memory Study.

ABSTRACT:

Introduction

Particulate air pollutants may induce neurotoxicity by increasing homocysteine levels, which can be lowered by high B vitamin intakes. Therefore, we examined whether intakes of three B vitamins (folate, B₁₂ , and B₆ ) modified the association between PM_2.5 exposure and incidence of all-cause dementia.

Methods

This study included 7183 women aged 65 to 80 years at baseline. B vitamin intakes from diet and supplements were estimated by food frequency questionnaires at baseline. The 3-year average PM_2.5 exposure was estimated using a spatiotemporal model.

Results

During a mean follow-up of 9 years, 342 participants developed all-cause dementia. We found that residing in locations with PM_2.5 exposure above

SUBMITTER: Chen C 

PROVIDER: S-EPMC9339592 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature