Dataset Information
B vitamin intakes modify the association between particulate air pollutants and incidence of all-cause dementia: Findings from the Women's Health Initiative Memory Study.
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ABSTRACT: Introduction
Particulate air pollutants may induce neurotoxicity by increasing homocysteine levels, which can be lowered by high B vitamin intakes. Therefore, we examined whether intakes of three B vitamins (folate, B12 , and B6 ) modified the association between PM2.5 exposure and incidence of all-cause dementia.Methods
This study included 7183 women aged 65 to 80 years at baseline. B vitamin intakes from diet and supplements were estimated by food frequency questionnaires at baseline. The 3-year average PM2.5 exposure was estimated using a spatiotemporal model.Results
During a mean follow-up of 9 years, 342 participants developed all-cause dementia. We found that residing in locations with PM2.5 exposure above the regulatory standard (12 μg/m3 ) was associated with a higher risk of dementia only among participants with lower intakes of these B vitamins.Discussion
This is the first study suggesting that the putative neurotoxicity of PM2.5 exposure may be attenuated by high B vitamin intakes.
SUBMITTER: Chen C
PROVIDER: S-EPMC9339592 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Publications
B vitamin intakes modify the association between particulate air pollutants and incidence of all-cause dementia: Findings from the Women's Health Initiative Memory Study.
Alzheimer's & dementia : the journal of the Alzheimer's Association 20220201 11
<h4>Introduction</h4>Particulate air pollutants may induce neurotoxicity by increasing homocysteine levels, which can be lowered by high B vitamin intakes. Therefore, we examined whether intakes of three B vitamins (folate, B<sub>12</sub> , and B<sub>6</sub> ) modified the association between PM<sub>2.5</sub> exposure and incidence of all-cause dementia.<h4>Methods</h4>This study included 7183 women aged 65 to 80 years at baseline. B vitamin intakes from diet and supplements were estimated by fo ...[more]