Ablation and antiarrhythmic drug effects on PITX2 ^+/- deficient atrial fibrillation: A computational modeling study.

ABSTRACT:

Introduction

Atrial fibrillation (AF) is a heritable disease, and the paired-like homeodomain transcription factor 2 (PITX2) gene is highly associated with AF. We explored the differences in the circumferential pulmonary vein isolation (CPVI), which is the cornerstone procedure for AF catheter ablation, additional high dominant frequency (DF) site ablation, and antiarrhythmic drug (AAD) effects according to the patient genotype (wild-type and PITX2 ^+/- deficient) using computational modeling.

Methods

We included 25 patients with AF (68% men, 59.8 ± 9.8 years of age, 32% paroxysmal AF) who underwent AF catheter ablation to develop a realistic computational AF model. The ion currents for baseline AF and the amiodarone, dronedarone, and flecainide AADs

SUBMITTER: Jin Z 

PROVIDER: S-EPMC9343754 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature