Targeted delivery of irinotecan to colon cancer cells using epidermal growth factor receptor-conjugated liposomes.

ABSTRACT:

Background

CPT-11 (irinotecan) is one of the most efficient agents used for colorectal cancer chemotherapy. However, as for many other chemotherapeutic drugs, how to minimize the side effects of CPT-11 still needs to be thoroughly described.

Objectives

This study aimed to develop the CPT-11-loaded DSPE-PEG 2000 targeting EGFR liposomal delivery system and characterize its targeting specificity and therapeutic effect on colorectal cancer (CRC) cells in vitro and in vivo.

Results

The synthesized liposome exhibited spherical shapes (84.6 ± 1.2 nm to 150.4 nm ± 0.8 nm of estimated average sizes), good stability, sustained release, and enough drug loading (55.19%). For in vitro experiments, SW620 cells treated with CPT-11-loaded DSPE-PEG₂₀₀₀ targeting EGFR lipos

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9344698 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature