T-cell recovery and evidence of persistent immune activation 12 months after severe COVID-19.

ABSTRACT:

Background

T-cell lymphopenia and functional impairment is a hallmark of severe acute coronavirus disease 2019 (COVID-19). How T-cell numbers and function evolve at later timepoints after clinical recovery remains poorly investigated.

Methods

We prospectively enrolled and longitudinally sampled 173 individuals with asymptomatic to critical COVID-19 and analyzed phenotypic and functional characteristics of T cells using flow cytometry, 40-parameter mass cytometry, targeted proteomics, and functional assays.

Results

The extensive T-cell lymphopenia observed particularly in patients with severe COVID-19 during acute infection had recovered 6 months after infection, which was accompanied by a normalization of functional T-cell responses to common viral antigens. We detect

SUBMITTER: Taeschler P 

PROVIDER: S-EPMC9347640 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature