Antibody levels to SARS-CoV-2 spike protein in mothers and children from delivery to six months later.

ABSTRACT:

Introduction

Pregnant women are vulnerable to severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection. Neutralizing antibodies against the SARS-CoV-2 spike (S) protein protect from severe disease. This study analyzes the antibody titers to SARS-CoV-2 S protein in pregnant women and their newborns at delivery, and six months later.

Methods

We conducted a prospective study on pregnant women with confirmed SARS-CoV-2 infection and newborns. Antibody (IgG, IgM, and IgA) titers were determined using immunoassays in serum and milk samples. An angiotensin-converting enzyme 2 (ACE2) receptor-binding inhibition assay to the S protein was performed on the same serum and milk samples.

Results

At birth, antibodies to SARS-CoV-2 spike protein were detected in 81.9% of

SUBMITTER: Martin-Vicente M 

PROVIDER: S-EPMC9349436 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature