Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis.

ABSTRACT: The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid tumours that plays a crucial role in shaping their progression. Many desmoplastic tumours including breast cancer involve the significant accumulation of type I collagen. However, recently it has become clear that the precise distribution and organisation of matrix molecules such as collagen I is equally as important in the tumour as their abundance. Cancer-associated fibroblasts (CAFs) coexist within breast cancer tissues and play both pro- and anti-tumourigenic roles through remodelling the ECM. Here, using temporal proteomic profiling of decellularized tumours, we interrogate the evolving matrisome during breast cancer progression. We identify 4 key matrisomal clusters, and pinpoint collag

SUBMITTER: Papanicolaou M 

PROVIDER: S-EPMC9357007 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature