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Total Synthesis of Kibdelomycin.

ABSTRACT: A modular total synthesis of kibdelomycin is disclosed that should enable structure-activity relationship (SAR) studies of this interesting class of antibiotics. The route uses simple building blocks and addresses lingering questions about its structural assignment and relationship to amycolamicin, a recently described natural product reported to have a similar structure. Initial antibacterial assays reveal that both C-22 epimers (the N-glycosidic linkage) of the natural product have similar activity while structurally truncated analogs lose activity.

SUBMITTER: He C

PROVIDER: S-EPMC9357209 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Total Synthesis of Kibdelomycin.

He Chi C Wang Yu Y Bi Cheng C Peters David S DS Gallagher Timothy J TJ Teske Johannes J Chen Jason S JS Corsetti Rachel R D'Onofrio Anthony A Lewis Kim K Baran Phil S PS

Angewandte Chemie (International ed. in English) 20220706 32

A modular total synthesis of kibdelomycin is disclosed that should enable structure-activity relationship (SAR) studies of this interesting class of antibiotics. The route uses simple building blocks and addresses lingering questions about its structural assignment and relationship to amycolamicin, a recently described natural product reported to have a similar structure. Initial antibacterial assays reveal that both C-22 epimers (the N-glycosidic linkage) of the natural product have similar act ...[more]

PMID: 35704446

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