Trajectory of low-density lipoprotein cholesterol in patients with chronic kidney disease and its association with cardiovascular disease.

ABSTRACT:

Background

The role of longitudinal temporal trends in LDL-C in cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) and diabetes is unclear. This study categorized the long-term LDL-C trajectory and determined its association with the incidence of atherosclerotic CVD in patients with CKD according to diabetes status and estimated glomerular filtration rate (eGFR).

Methods

The risk of atherosclerotic CVD was estimated in 137,127 Taiwanese patients with CKD using six LDL-C trajectory classes determined by the latent class mixed model as optimal, near optimal, above optimal, borderline, sustained high, and declined high over 5 years.

Results

The risk of CVD was higher in the sustained high LDL-C [>160 mg/dL over time; adjusted hazard ratio (aHR) =

SUBMITTER: Wang SW 

PROVIDER: S-EPMC9360605 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature