Dataset Information
The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series.
Ontology highlight
ABSTRACT: Background
Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na+, K+-ATPase causing lysis of highly malignant cancer cells. Hypothesis/Objectives. TOL offers an option for treating advanced carcinomas in companion animals. Animals. Two cats and 2 dogs that presented to veterinary hospitals for evaluation and treatment of one of several forms of carcinoma.Methods
Digoxin was administered to achieve steady-state, therapeutic concentrations. The animals were then exposed to pulsed electric field stimulation. Pre- and posttreatment assessments of tumor size and quality of life were compared. The treatment frequency and survivability varied, based on the patient's premorbid functioning and response to treatment.Results
Regardless of cancer type, TOL consistently increased survival beyond expected, often improving, but without compromising of quality of life. Conclusions and Clinical Importance. TOL warrants consideration as an option for managing advanced carcinomas.
SUBMITTER: Gould HJ
PROVIDER: S-EPMC9363929 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series.
Case reports in veterinary medicine 20220802
<h4>Background</h4>Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na<sup>+</sup>, K<sup>+</sup>-ATPase causing lysis of highly malignant cancer cells. <i>Hypothesis/Objectives</i>. TOL offers an option for treating advanced carcinomas in companion animals. <i>Animals</i>. Two cats and 2 dogs that presented to veterinary hospitals for evaluation and treatment of one of several fo ...[more]