Association of Dual Antiplatelet Therapy With Ticagrelor With Vein Graft Failure After Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

The role of ticagrelor with or without aspirin after coronary artery bypass graft surgery remains unclear.

Objective

To compare the risks of vein graft failure and bleeding associated with ticagrelor dual antiplatelet therapy (DAPT) or ticagrelor monotherapy vs aspirin among patients undergoing coronary artery bypass graft surgery.

Data sources

MEDLINE, Embase, and Cochrane Library databases from inception to June 1, 2022, without language restriction.

Study selection

Randomized clinical trials (RCTs) comparing the effects of ticagrelor DAPT or ticagrelor monotherapy vs aspirin on saphenous vein graft failure.

Data extraction and synthesis

Individual patient data provided by each trial were synthesized into a combined data set for independent

SUBMITTER: Sandner S 

PROVIDER: S-EPMC9364127 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature