4-bit adhesion logic enables universal multicellular interface patterning.

ABSTRACT: Multicellular systems, from bacterial biofilms to human organs, form interfaces (or boundaries) between different cell collectives to spatially organize versatile functions^1,2. The evolution of sufficiently descriptive genetic toolkits probably triggered the explosion of complex multicellular life and patterning^3,4. Synthetic biology aims to engineer multicellular systems for practical applications and to serve as a build-to-understand methodology for natural systems^5-8. However, our ability to engineer multicellular interface patterns^2,9 is still very limited, as synthetic cell-cell adhesion toolkits and suitable patterning algorithms are underdeveloped^5,7,10-13. Here we introduce a synthetic cell-cell adhesin logic with swarming bact

SUBMITTER: Kim H 

PROVIDER: S-EPMC9365691 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature