Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development.

ABSTRACT: T cells are generated from hematopoietic stem cells through a highly organized developmental process, in which stage-specific molecular events drive maturation towards αβ and γδ T cells. Although many of the mechanisms that control αβ- and γδ-lineage differentiation are shared between human and mouse, important differences have also been observed. Here, we studied the regulatory dynamics of the E and ID protein encoding genes during pediatric human T cell development by evaluating changes in chromatin accessibility, histone modifications and bulk and single cell gene expression. We profiled patterns of ID/E protein activity and identified up- and downstream regulators and targets, respectively. In addition, we compared transcription of E and ID protein encoding genes in human versus mouse

SUBMITTER: Roels J 

PROVIDER: S-EPMC9366357 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature