Regulation of CD4⁺ and CD8⁺ T Cell Biology by Short-Chain Fatty Acids and Its Relevance for Autoimmune Pathology.

ABSTRACT: The gut microbiota encodes a broad range of enzymes capable of synthetizing various metabolites, some of which are still uncharacterized. One well-known class of microbiota-derived metabolites are the short-chain fatty acids (SCFAs) such as acetate, propionate, butyrate and valerate. SCFAs have long been considered a mere waste product of bacterial metabolism. Novel results have challenged this long-held dogma, revealing a central role for microbe-derived SCFAs in gut microbiota-host interaction. SCFAs are bacterial signaling molecules that act directly on host T lymphocytes by reprogramming their metabolic activity and epigenetic status. They have an essential biological role in promoting differentiation of (intestinal) regulatory T cells and in production of the anti-inflammatory cytokin

SUBMITTER: Schiweck C 

PROVIDER: S-EPMC9368239 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature