Hydrogen Sulfide and Substance P Levels in Patients with Escherichia coli and Klebsiella pneumoniae Bacteraemia.

ABSTRACT: Hydrogen sulfide (H₂S) and substance P (SP) are known from animal models and in vitro studies as proinflammatory mediators. In this study, peripheral blood concentrations of H₂S and SP were measured in patients with Escherichia coli or Klebsiella pneumoniae bacteraemia. Fifty patients were recruited from general wards at Christchurch Hospital, during 2020-2021. Samples from age- and sex-matched healthy subjects previously recruited as controls for studies of cardiovascular disease were used as controls. The concentrations of H₂S were higher than controls on day 0, day 1, and day 2, and SP was higher than controls on all 4 days. The concentrations of H₂S were highest on day 0, whereas SP concentrations were higher on day 2 than other

SUBMITTER: Manandhar S 

PROVIDER: S-EPMC9368963 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature