Unravelling the Adaptation Mechanisms to High Pressure in Proteins.
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ABSTRACT:
SUBMITTER: Calio A
PROVIDER: S-EPMC9369236 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Publications
Unravelling the Adaptation Mechanisms to High Pressure in Proteins.
Caliò Antonino A Dubois Cécile C Fontanay Stéphane S Koza Michael Marek MM Hoh François F Roumestand Christian C Oger Philippe P Peters Judith J
International journal of molecular sciences 20220730 15
Life is thought to have appeared in the depth of the sea under high hydrostatic pressure. Nowadays, it is known that the deep biosphere hosts a myriad of life forms thriving under high-pressure conditions. However, the evolutionary mechanisms leading to their adaptation are still not known. Here, we show the molecular bases of these mechanisms through a joint structural and dynamical study of two orthologous proteins. We observed that pressure adaptation involves the decoupling of protein-water ...[more]
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