Chelating the Alpha Therapy Radionuclides ²²⁵Ac³⁺ and ²¹³Bi³⁺ with 18-Membered Macrocyclic Ligands Macrodipa and Py-Macrodipa.

ABSTRACT: The radionuclides ²²⁵Ac³⁺ and ²¹³Bi³⁺ possess favorable physical properties for targeted alpha therapy (TAT), a therapeutic approach that leverages α radiation to treat cancers. A chelator that effectively binds and retains these radionuclides is required for this application. The development of ligands for this purpose, however, is challenging because the large ionic radii and charge-diffuse nature of these metal ions give rise to weaker metal-ligand interactions. In this study, we evaluated two 18-membered macrocyclic chelators, macrodipa and py-macrodipa, for their ability to complex ²²⁵Ac³⁺ and ²¹³Bi³⁺. Their coordination chemistry with Ac³⁺ was probed computationally and with Bi^3+</

SUBMITTER: Hu A 

PROVIDER: S-EPMC9372718 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature