CXCR4^high megakaryocytes regulate host-defense immunity against bacterial pathogens.

ABSTRACT: Megakaryocytes (MKs) continuously produce platelets to support hemostasis and form a niche for hematopoietic stem cell maintenance in the bone marrow. MKs are also involved in inflammatory responses; however, the mechanism remains poorly understood. Using single-cell sequencing, we identified a CXCR4 highly expressed MK subpopulation, which exhibited both MK-specific and immune characteristics. CXCR4^high MKs interacted with myeloid cells to promote their migration and stimulate the bacterial phagocytosis of macrophages and neutrophils by producing TNFα and IL-6. CXCR4^high MKs were also capable of phagocytosis, processing, and presenting antigens to activate T cells. Furthermore, CXCR4^high MKs also egressed circulation and infiltrated into the spleen, liver,

SUBMITTER: Wang J 

PROVIDER: S-EPMC9374440 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature