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Pazopanib Is a Potential Treatment for Coronavirus-Induced Lung Injuries.


ABSTRACT: Severe acute respiratory syndrome coronavirus 2, responsible for the severe acute respiratory syndrome known as COVID-19, has rapidly spread in almost every country and devastated the global economy and health care system. Lung injury is an early disease manifestation believed to be a major contributor to short- and long-term pathological consequences of COVID-19, and thus drug discovery aiming to ameliorate lung injury could be a potential strategy to treat COVID-19 patients. By inducing a severe acute respiratory syndrome-like pulmonary disease model through infecting A/J mice with murine hepatitis virus strain 1 (MHV-1), we show that i.v. administration of pazopanib ameliorates acute lung injuries without affecting MHV-1 replication. Pazopanib reduces cell apoptosis in MHV-1-infected lungs. Furthermore, we also identified that pazopanib has to be given no later than 48 h after the virus infection without compromising the therapeutic effect. Our study provides a potential treatment for coronavirus-induced lung injuries and support for further evaluation of pazopanib in COVID-19 patients.

SUBMITTER: Luan Y 

PROVIDER: S-EPMC9378470 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Pazopanib Is a Potential Treatment for Coronavirus-Induced Lung Injuries.

Luan Yi Y   Yuan Qianying Q   Wang Qijun Q   Compton Susan S   Wu Dianqing D   Tang Wenwen W  

Journal of immunology (Baltimore, Md. : 1950) 20220801 4


Severe acute respiratory syndrome coronavirus 2, responsible for the severe acute respiratory syndrome known as COVID-19, has rapidly spread in almost every country and devastated the global economy and health care system. Lung injury is an early disease manifestation believed to be a major contributor to short- and long-term pathological consequences of COVID-19, and thus drug discovery aiming to ameliorate lung injury could be a potential strategy to treat COVID-19 patients. By inducing a seve  ...[more]

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