Genetic insights into therapeutic targets for aortic aneurysms: A Mendelian randomization study.

ABSTRACT:

Background

As aortic aneurysms (AAs) enlarge, they can become life-threatening if left undiagnosed or neglected. At present, there is a lack of radical treatments for preventing disease progression. Therefore, we aimed to identify effective drug targets that slow the progression of AAs.

Methods

A Mendelian randomization (MR) analysis was conducted to identify therapeutic targets which are associated with AAs. Summary statistics for AAs were obtained from two datasets: the UK Biobank (2228 cases and 408,565 controls) and the FinnGen study (3658 cases and 244,907 controls). Cis-expression quantitative trait loci (cis-eQTL) for druggable genes were retrieved from the eQTLGen Consortium and used as genetic instrumental variables. Colocalization analysis was performed to determin

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9385553 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature