Ontology highlight
ABSTRACT:
SUBMITTER: Noori M
PROVIDER: S-EPMC9386204 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Noori Milad M Davoodi Ali A Iraji Aida A Dastyafteh Navid N Khalili Minoo M Asadi Mehdi M Mohammadi Khanaposhtani Maryam M Mojtabavi Somayeh S Dianatpour Mehdi M Faramarzi Mohammad Ali MA Larijani Bagher B Amanlou Massoud M Mahdavi Mohammad M
Scientific reports 20220818 1
In this study, 18 novel quinoline-based-benzo[d]imidazole derivatives were synthesized and screened for their α-glucosidase inhibitory potential. All compounds in the series except 9q showed a significant α-glucosidase inhibition with IC<sub>50</sub> values in the range of 3.2 ± 0.3-185.0 ± 0.3 µM, as compared to the standard drug acarbose (IC<sub>50</sub> = 750.0 ± 5.0 µM). A kinetic study indicated that compound 9d as the most potent derivative against α-glucosidase was a competitive type inhi ...[more]