Relationships of Glucose, GLP-1, and Insulin Secretion With Gastric Emptying After a 75-g Glucose Load in Type 2 Diabetes.

ABSTRACT:

Context

The relationships of gastric emptying (GE) with the glycemic response at 120 minutes, glucagon-like peptide-1 (GLP-1), and insulin secretion following a glucose load in type 2 diabetes (T2D) are uncertain.

Objective

We evaluated the relationship of plasma glucose, GLP-1, and insulin secretion with GE of a 75-g oral glucose load in T2D.

Design

Single-center, cross-sectional, post hoc analysis.

Setting

Institutional research center.

Participants

43 individuals with T2D age 65.6 ± 1.1 years, hemoglobin A1c 7.2 ± 1.0%, median duration of diabetes 5 years managed by diet and/or metformin.

Intervention

Participants consumed the glucose drink radiolabeled with 99mTc-phytate colloid following an overnight fast. GE (scintigraphy), plasma glucose, G

SUBMITTER: Jalleh RJ 

PROVIDER: S-EPMC9387705 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature