Brain network analysis of interictal epileptiform discharges from ECoG to identify epileptogenic zone in pediatric patients with epilepsy and focal cortical dysplasia type II: A retrospective study.

ABSTRACT:

Objective

For patients with drug-resistant focal epilepsy, intracranial monitoring remains the gold standard for surgical intervention. Focal cortical dysplasia (FCD) is the most common cause of pharmacoresistant focal epilepsy in pediatric patients who usually develop seizures in early childhood. Timely removal of the epileptogenic zone (EZ) is necessary to achieve lasting seizure freedom and favorable developmental and cognitive outcomes to improve the quality of life. We applied brain network analysis to investigate potential biomarkers for the diagnosis of EZ that will aid in the resection for pediatric focal epilepsy patients with FCD type II.

Methods

Ten pediatric patients with focal epilepsy diagnosed as FCD type II and that had a follow-up after resection surgery (En

SUBMITTER: Wang ZJ 

PROVIDER: S-EPMC9388828 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature