Time-dependent recovery of brain hypometabolism in neuro-COVID-19 patients.

ABSTRACT:

Purpose

We evaluated brain metabolic dysfunctions and associations with neurological and biological parameters in acute, subacute and chronic COVID-19 phases to provide deeper insights into the pathophysiology of the disease.

Methods

Twenty-six patients with neurological symptoms (neuro-COVID-19) and [¹⁸F]FDG-PET were included. Seven patients were acute (< 1 month (m) after onset), 12 subacute (4 ≥ 1-m, 4 ≥ 2-m and 4 ≥ 3-m) and 7 with neuro-post-COVID-19 (3 ≥ 5-m and 4 ≥ 7-9-m). One patient was evaluated longitudinally (acute and 5-m). Brain hypo- and hypermetabolism were analysed at single-subject and group levels. Correlations between severity/extent of brain hypo- and hypermetabolism and biological (oxygen saturation and C-reactive protein) and clinical vari

SUBMITTER: Martini AL 

PROVIDER: S-EPMC9388976 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature