Inflammatory and immune checkpoint markers are associated with the severity of aortic stenosis.

ABSTRACT:

Objective

Aortic stenosis (AS) is a disease characterized by narrowing of the aortic valve (AV) orifice. In relation to this disease, the purpose of this study was to elucidate the relationships among factors such as expression of programmed cell death-1 ligand (PD-L1, which is the ligand of PD-1 protein; together, they play a central role in the inhibition of T lymphocyte function), clinicopathologic characteristics, infiltrating immune cells, and disease severity.

Methods

We performed immunohistochemical analysis on the surgically-resected AVs of 53 patients with AS. We used the resultant data to identify relationships among PD-L1 expression, disease severity, and the infiltration of immune cells including cluster of differentiation (CD8)-positive T lymphocytes, cluster of

SUBMITTER: Erkhem-Ochir B 

PROVIDER: S-EPMC9390628 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature