Logic of the Temporal Compartmentalization of the Hepatic Metabolic Cycle.

ABSTRACT: The mammalian liver must cope with various metabolic and physiological changes that normally recur every day and result primarily from rest-activity and fasting-feeding cycles. In this article, I present evidence supporting a temporal compartmentalization of rhythmic hepatic metabolic processes into four main clusters: regulation of energy homeostasis, maintenance of information integrity, immune response, and genetic information flow. I further review literatures and discuss how both the circadian and the newly discovered 12-h ultradian clock work together to regulate these four temporally separated processes in mouse liver, which, interestingly, is largely uncoupled from the liver zonation regulation.

SUBMITTER: Zhu B 

PROVIDER: S-EPMC9394779 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature