β-sheets in serum protein are independent risk factors for coronary lesions besides LDL-C in coronary heart disease patients.

ABSTRACT:

Background

Coronary heart disease (CHD) patients with standard low-density lipoprotein cholesterol (LDL-C) remain at risk of cardiovascular events, making it critical to explore new targets to reduce the residual risk. The relationship between β-sheet conformation and CHD is gaining attention. This study was designed to compare the coronary lesions in CHD patients with varying LDL-C and evaluate whether serum β-sheets are associated with coronary damage.

Methods

Two hundred and one patients diagnosed with stable CHD were recruited and divided into four groups according to LDL-C. Baseline information, coronary lesion-related indicators, and peripheral blood samples were collected. Serum β-sheet content was determined by thioflavin T fluorescence.

Results

The baseline i

SUBMITTER: Li YL 

PROVIDER: S-EPMC9395970 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature