A Randomized, Double-Blinded Crossover Trial of Short Versus Conventional Pulse Width Subthalamic Deep Brain Stimulation in Parkinson's Disease.

ABSTRACT:

Background

Subthalamic nucleus deep brain stimulation (STN-DBS) is a well-established treatment for patients with Parkinson's disease. Previous acute challenge studies suggested that short pulse widths might increase the therapeutic window while maintaining motor symptom control with a decrease in energy consumption. However, only little is known about the effect of short pulse width stimulation beyond the setting of an acute challenge.

Objective

To compare 4 weeks of STN-DBS with conventional pulse width stimulation (60 μs) to 4 weeks of STN-DBS with short pulse width stimulation (30 μs) regarding motor symptom control.

Methods

This study was a monocentric, double-blinded, randomized crossover non-inferiority trial investigating whether short pulse width stimulation

SUBMITTER: Petry-Schmelzer JN 

PROVIDER: S-EPMC9398064 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature