Impact of AKT1 polymorphism on DNA damage, BTG2 expression, and risk of colorectal cancer development.

ABSTRACT:

Background

AKT, also called protein kinase B, is a serine-threonine kinase that functions as a mediator of PI3K-Akt-mTOR signaling pathway and plays an important role in an array of cellular processes. Many single nucleotide polymorphisms (SNP) in AKT gene have been observed to be associated with various types of cancers. In the current research the association of a functional SNP rs1130233 in AKT, depicting G to A transition, was studied with AKT activation, DNA damage, an early response B-cell translocation gene 2 (Btg2) expression and risk of colorectal cancer (CRC) development.

Patients and methods

A total 197 population-based controls and 200 CRC patients were genotyped for SNP rs1130233. AKT expression, activation and BTG2 expression were determine

SUBMITTER: Zubair H 

PROVIDER: S-EPMC9400445 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature