Influence of gestational diabetes mellitus on lipid signatures in breast milk and association with fetal physical development.

ABSTRACT: Gestational diabetes mellitus (GDM) commonly leads to adverse pregnancy outcomes and long-term metabolic complications in offspring. Breastfeeding has been shown to rewrite the fetal "metabolic programming" resulting from maternal diabetes and finally lead to a lower risk of future metabolic disease. Lipids in breast milk act like hormones to promote infant growth and development, but there is minimal information invested thus far in constitution changes of lipids in breast milk, especially in the context of GDM. In the present study, we performed a lipidomics analysis to compare the lipid composition in breast milk collected from women with or without GDM. We further revealed the correlations of dysregulated lipids in breast milk with maternal glucose and infant physical development. A to

SUBMITTER: Zhong H 

PROVIDER: S-EPMC9402091 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature