Induction, decay, and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children.

ABSTRACT:

Background

RTS,S is the first malaria vaccine recommended for implementation among young children at risk. However, vaccine efficacy is modest and short-lived. Antibodies play the major role in vaccine-induced immunity, but knowledge on the induction, decay, and determinants of antibody function is limited, especially among children. Antibodies that promote opsonic phagocytosis and other cellular functions appear to be important contributors to RTS,S immunity.

Methods

We studied a phase IIb trial of RTS,S/AS02 conducted in young children in malaria-endemic regions of Mozambique. We evaluated the induction of antibodies targeting the circumsporozoite protein (CSP, vaccine antigen) that interact with Fcγ-receptors (FcRγs) and promote phagocytosis (neutrophils, monocytes, THP-1

SUBMITTER: Feng G 

PROVIDER: S-EPMC9402280 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature