Sensitivity and specificity of amide proton transfer-weighted imaging for assessing programmed death-ligand 1 status in non-small cell lung cancer: a comparative study with intravoxel incoherent motion and ¹⁸F-FDG PET.

ABSTRACT:

Background

Noninvasive assessment of programmed death-ligand 1 (PD-L1) expression status in non-small cell lung cancer (NSCLC) is necessary. This study arm to investigate the value of 2-[¹⁸F]-fluoro-2-deoxy-D-glucose positron emission tomography (¹⁸F-FDG PET), diffusion-weighted imaging (DWI), intravoxel incoherent motion (IVIM), and amide proton transfer-weighted imaging (APTWI) in the assessment of PD-L1 status in NSCLC.

Methods

This is a prospective diagnostic study. A total of 76 patients with NSCLC underwent chest ¹⁸F-FDG PET/magnetic resonance imaging (MRI). Parameters maximum standardized uptake value (SUV_max), quantitate the metabolic tumor volume (MTV), total lesion glycolysis (TLG), apparent diffusion coefficient (ADC), d

SUBMITTER: Meng N 

PROVIDER: S-EPMC9403585 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature