Body mass index trajectories, weight gain and risks of liver and biliary tract cancers.

ABSTRACT:

Background

Little is known about the role of early obesity or weight change during adulthood in the development of liver cancer and biliary tract cancer (BTC).

Methods

We investigated the associations of body mass index (BMI) and weight trajectories with the risk of liver cancer and BTC in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO). BMI was self-reported at ages 20, 50, and at enrollment. BMI trajectories were determined using latent class growth models. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

During a median follow-up of 15.9 years among 138,922 participants, 170 liver cancer and 143 BTC cases were identified. Compared with those whose BMI does not exceed 25 kg/m2, participants

SUBMITTER: Yang W 

PROVIDER: S-EPMC9406603 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature