Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma.

ABSTRACT: Pregnant women are at greater risk of adverse outcomes, including mortality, as well as obstetrical complications resulting from COVID-19. However, pregnancy-specific changes that underlie such worsened outcomes remain unclear. Herein, we profiled the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls and showed alterations that display a dose-response relationship with disease severity; yet, such proteomic perturbations are dampened during pregnancy. In both pregnant and non-pregnant state, the proteome response induced by COVID-19 showed enrichment of mediators implicated in cytokine storm, endothelial dysfunction, and angiogenesis. Shared and pregnancy-specific proteomic changes were identified: pregnant women display a tailored response that may protect the con

SUBMITTER: Gomez-Lopez N 

PROVIDER: S-EPMC9413722 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature