Transmission dynamics of the 2016-18 outbreak of hepatitis A among men who have sex with men in England and cost-effectiveness analysis of vaccination strategies to prevent future outbreaks.

ABSTRACT:

Background

Despite being vaccine-preventable, hepatitis A virus (HAV) outbreaks occur among men who have sex with men (MSM). We modelled the cost-effectiveness of vaccination strategies to prevent future outbreaks.

Methods

A HAV transmission model was calibrated to HAV outbreak data for MSM in England over 2016-2018, producing estimates for the basic reproduction number (R₀) and immunity levels (seroprevalence) post-outbreak. For a hypothetical outbreak in 2023 (same R₀ and evolving immunity), the cost-effectiveness of pre-emptive (vaccination between outbreaks among MSM attending sexual health services (SHS)) and reactive (vaccination during outbreak among MSM attending SHS and primary care) vaccination strategies were modelled. Effectiveness in qualit

SUBMITTER: Zhang XS 

PROVIDER: S-EPMC9417902 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature