Polymorphism in GRHL2 gene may contribute to noise-induced hearing loss susceptibility: a meta-analysis.

ABSTRACT:

Instruction

Noise-induced hearing loss is a leading occupational disease caused by gene-environment interaction. The Grainy Like 2, GRHL2, is a candidate gene. In this regard, many studies have evaluated the association between GRHL2 and noise-induced hearing loss, although the results are ambiguous and conflicting.

Objective

The purpose of this study was to identify a precise estimation of the association between rs3735715 polymorphism in GRHL2 gene and susceptibility of noise-induced hearing loss.

Methods

A comprehensive search was performed to collect data up to July 8, 2018. Finally, 4 eligible articles were included in this meta-analysis comprising 2410 subjects. The pooled odds ratios with 95% confidence intervals were used to evaluate the strength of the associ

SUBMITTER: Li X 

PROVIDER: S-EPMC9422585 | biostudies-literature | 2020 May - Jun

REPOSITORIES: biostudies-literature