Magnetoelectric core-shell CoFe₂O₄@BaTiO₃ nanorods: their role in drug delivery and effect on multidrug resistance pump activity in vitro.

ABSTRACT: Nanoparticle mediated targeted drug delivery has become a widespread area of cancer research to address premature drug delivery problems. We report the synthesis of magneto-electric (ME) core-shell cobalt ferrite-barium titanate nanorods (CFO@BTO NRs) to achieve "on demand" drug release in vitro. Physical characterizations confirmed the formation of pure CFO@BTO NRs with appropriate magnetic and ferroelectric response, favorable for an externally controlled drug delivery system. Functionalization of NRs with doxorubicin (DOX) and methotrexate (MTX) achieved up to 98% drug release in 20 minutes, under a 4 mT magnetic field (MF). We observed strong MF and dose dependent cytotoxic response in HepG2 and HT144 cells and 3D spheroid models (p < 0.05). Cytotoxicity was characterized

SUBMITTER: Mushtaq S 

PROVIDER: S-EPMC9434104 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature